Saturday and Sunday 周末◆Have a good weekend! 周末愉快！◆(BrE) The office is closed at the weekend. 办公室周末不开放。◆(especially NAmE) The office is closed on the weekend. 办公室在周末不开放。
Saturday and Sunday, or a slightly longer period, as a holiday/vacation 周末休假◆a weekend break 周末休假